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Debottlenecking

Debottlenecking by Continuous Manufacturing: Capacity Increase by 50% and Doubled Yield gave an Efficiency Boost

In the past, this customer of Microinnova had produced the same fine chemical product in four batch vessels. Microinnova developed a continuous process for fine chemical products (Batch-to-Conti). This process was scaled up to manufacturing by designing a continuous plant, using 2 of the 4 existing vessels. The redesigned plant enables an increase of the production volume by 50 % and a doubling of the yield. The manpower previously needed for production was reduced by 90 % after the plant had been automated and switched form manual operation to supervision of the automated manufacturing. 

 

Microinnova developed a continuous process for fine chemical products (Batch-to-Conti). This process was scaled up to manufacturing by designing a continuous plant, using 2 of the 4 existing vessels. The redesigned plant enables an increase of the production volume by 50 % and a doubling of the yield.

 

Continuous Manufacturing Case Study: Efficiency concept for Injectables boosts manufacturing efficiency and reduces quality costs

Microinnova has developed a concept for an efficiency push in a manufacturing plant for injectables of a European Pharmaceuticals Global Player. The main aim of the project was the opportunity to generate a fundamental boost in efficiency for manufacturing. Continuous formulation plants enable complete mixing within minutes instead of hours, which reduces the reactor volumes by a factor of more than 100. Additionally, this leads to an increase in quality, since the batch process did not lead to a product within specification limits on the first attempt.  The batch process was tested and corrected until the product fit the tight specification resulting in high quality costs. The continuous solution enables quality control by PAT tools. 

 

 Continuous formulation plants enable complete mixing within minutes instead of hours, which reduces the reactor volumes by a factor of more than 100. Additionally, this leads to an increase in quality, since the batch process did not lead to a product within specification limits on the first attempt.

 

Capacity Boost by Batch-to-Conto Debottlenecking

Space economy is a typical issue fodebottlenecking projects. Since a continuous approach reduces mass and heat transfer distances up to a factor of 100, these solutions can easily be integrated into an existing batch environment. A number of different strategies can reduce or replace batch processing times. For example, a batch processing step can be translated into a continuous plant skid

In some cases, the mixing operation or even the reaction itself can be executed while filling the reactor. Reagents, especially hazardous ones, can be synthesized in situ. Large savings can be achieved in the field of acid-base-reactions, since they are characterized by a strong heat release. These kinds of processes can reduce residence times from hours to minutes, since they are limited by the heat exchange which can easily be controlled in a continuous device. Mobility of skids enables a flexible use in connection with different plants. Optimizing mass and heat transfer is an important factor in reducing the costs per kilogram, leading to an increased competitiveness.

  • Minimal intervention with maximum effect
  • Process simplified – first exothermic batch step switched to continuous
  • Production volume doubled
  • Cut-down energy costs

Investment costs were of about 1/10 of conventional plant costs!

 

Space economy is a typical issue for debottlenecking projects. Since a continuous approach reduces mass and heat transfer distances up to a factor of 100, these solutions can easily be integrated into an existing batch environment. A number of different strategies can reduce or replace batch processing times. For example, a batch processing step can be translated into a continuous plant skid.